Bioavailability (F) Practice Problems
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Absolute bioavailability compares how much drug reaches the systemic circulation from an oral dose versus an IV dose (which is 100% by definition). It is calculated from the dose-normalized areas under the concentration-time curve (AUC).
FormulaF = (AUC_oral ÷ Dose_oral) × (Dose_IV ÷ AUC_IV)
Worked example
IV 100 mg gives AUC 50; oral 200 mg gives AUC 60. First term: 60 ÷ 200 = 0.30; second term: 100 ÷ 50 = 2; F = 0.30 × 2 = 0.60 = 60%.
💡 Always dose-normalize both AUCs — comparing raw AUCs from different doses is the built-in trap.